Leon then finds a nearby helicopter and manages to fly it to a BSAA base, providing them with the evidence he found, thanking Leon for it. Simmons falls to the oceans below as the Family decided to leave him to die. Leon uses a nearby found cigarette from a corpse to blow it up, destroying both part of the bridge and Simmons. However after Leon manages to escape him most of the time, he finds gasoline along with multiple vehicles on a bridge as Simmons pursues him. The virus infecting him transforms his body into a centaur-looking beast, hellbent on killing Leon. Expecting him to bring him down with what he discovered and could use as evidence, Simmons ordered his men to kill him, but Leon evades them and a J'avo shoots Simmons with the C-Virus. Chris sets off to take a separate route as Leon takes his own path, where he encounters Simmons. After Leon mistakes her for Ada, Chris tells her she isn't but the woman disappears. Later, Leon comes across an Ada-lookalike woman and Chris Redfield. He is forced to journey through the market, going through a horde of humanoid creatures capable of dismantling their body parts. As the communication tower started burning and collapsed, Leon drove away and arrived at an indoor market.
The reunion was short however as Jake's hunter, Ustanak, caused their separation. Surviving the ordeal, Leon encounters Sherry Birkin and Jake Muller, the son of Albert Wesker. The monster caused the plane, flying over China at the time in his search for safe haven in another country, to crash-land on a cargo bay. Leon discovers a plane and uses it to escape Tall Oaks but it gets infiltrated by a Lepotica. As he drops out from the waterfall, Leon witnesses the thermobaric sterilizing of Tall Oaks, just like Raccoon City, bringing Leon back haunting memories. Leon escapes through the catacombs and is attacked by a shark-like B.O.W., which hunts him from the flooded catacombs into an underground waterfall, where he manages to escape it.
Simmons, the secretary of defense, is responsible for both her death and the entire outbreak. However, she turns out to be infected with the C-Virus and turns a monstrosity, to which Leon flees from but from help from Ada Wong, who manages to shoot the mutated woman in the heart, she is killed as she falls off a cliff and Leon discovers from a recording that Derek C. Deeper in the facility, he finds a girl named Helena Harper, who is already experiencing great pain and Leon attempts to rescue her and bring her to safety. Leon discovers a video labelled "Happy Birthday Ada Wong", which depicts a confusing birth of a woman who looks like Ada. Infecting survivors with it's gas, Leon escapes the abomination and enters an underground facility. After searching the cathedral and solving various puzzles, a passage opens but a Lepotica emerges.
Making his way through a cemetery and eventually enters the cathedral, which is also full of survivors. All of the survivors are killed gruesomely by the horde, the bus then falls off the cliff and Leon is the sole survivor.
The bus drives through heavy rain to reach a cathedral, which the driver believes to be a safe area for them, however a group of zombies causes the bus teetering off a cliff. After Leon helps in barricading and fending off the shop, it is eventually overrun by zombies and they are forced to use a school bus to escape, however the store owner and a Japanese man is killed during the event. Retreating through the streets, he makes it to a store where he meets up with other survivors. This led Leon through the train lines and into the center of Tall Oaks to find the entire city infected. Following on from there, he goes through the university to a police car and attempts to drive off, only to be flipped, causing him to use the sewer tunnels nearby. After he breaks out of the elevator, he runs through a parking lot and into a surveillance room. They eventually find his daughter, only for her to turn into a zombie and eat her father in an elevator before turning on Leon.
During the search he starts coughing and begins to make suspicious complaints of skin irritation. Kennedy through the campus in the search for his missing daughter, Liz. In the United States, President Adam Benford is about to "come clean" over the incident in Raccoon City in a seminar at Ivy University, Tall Oaks, when he himself mutated into a zombie during a surprise bioterror attack led by an unknown organization.